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Given the widespread use of the vaccine, it is important to investigate the safety profile of the vaccine strain, oka/biken varicella, in japanese patients. The first available vaccine was derived from the parental oka strain in japan in 1974. The live attenuated varicella vaccine (oka strain) was developed by takahashi in 1974, and it was registered in japan in 1986.

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The active ingredient is tested against live varicella vaccine reference.

Oka/merck varicella vaccine is a live attenuated vaccine produced from the oka strain of the herpesvirus varicella zoster virus (vzv).

Since then monovalent varicella vaccines have been made. Belongs to the class of varicella viral vaccines. The protective efficacy of varicella virus vaccine live (oka/merck) [hereafter referred to as varicella vaccine (oka/merck)] was established by: Varicella is a common childhood disease that can be prevented by a live attenuated vaccine.